Growth and differentiation of a long bone in limb development, repair and regeneration

Shiro Egawa, Shinichirou Miura, Hitoshi Yokoyama, Tetsuya Endo, Koji Tamura

    Research output: Contribution to journalReview article

    22 Citations (Scopus)


    Repair from traumatic bone fracture is a complex process that includes mechanisms of bone development and bone homeostasis. Thus, elucidation of the cellular/molecular basis of bone formation in skeletal development would provide valuable information on fracture repair and would lead to successful skeletal regeneration after limb amputation, which never occurs in mammals. Elucidation of the basis of epimorphic limb regeneration in amphibians would also provide insights into skeletal regeneration in mammals, since the epimorphic regeneration enables an amputated limb to re-develop the three-dimensional structure of bones. In the processes of bone development, repair and regeneration, growth of the bone is achieved through several events including not only cell proliferation but also aggregation of mesenchymal cells, enlargement of cells, deposition and accumulation of extracellular matrix, and bone remodeling.

    Original languageEnglish
    Pages (from-to)410-424
    Number of pages15
    JournalDevelopment Growth and Differentiation
    Issue number5
    Publication statusPublished - 2014 Jun


    • Bone
    • Differentiation
    • Fracture
    • Growth
    • Regeneration

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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