TY - JOUR
T1 - Green tea consumption and gastric cancer in Japanese
T2 - A pooled analysis of six cohort studies
AU - Inoue, M.
AU - Sasazuki, S.
AU - Wakai, K.
AU - Suzuki, T.
AU - Matsuo, K.
AU - Shimazu, T.
AU - Tsuji, I.
AU - Tanaka, K.
AU - Mizoue, T.
AU - Nagata, C.
AU - Tamakoshi, A.
AU - Sawada, N.
AU - Tsugane, S.
PY - 2009/10
Y1 - 2009/10
N2 - Background: Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting. Objective: To examine the association between green tea consumption and gastric cancer. Methods: We analysed original data from six cohort studies that measured green tea consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model. Results: During 2 285 968 person-years of follow-up for a total of 219 080 subjects, 3577 cases of gastric cancer were identified. Compared with those drinking <1 cup/day, no significant risk reduction for gastric cancer was observed with increased green tea consumption in men, even in stratified analyses by smoking status and subsite. In women, however, a significantly decreased risk was observed for those with consumption of ≥5 cups/day (multivariate-adjusted pooled HR = 0.79, 95% confidence interval (CI) = 0.65 to 0.96). This decrease was also significant for the distal subsite (HR = 0.70, 95% CI = 0.50 to 0.96). In contrast, a lack of association for proximal gastric cancer was consistently seen in both men and women. Conclusions: Green tea may decrease the risk of distal gastric cancer in women.
AB - Background: Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting. Objective: To examine the association between green tea consumption and gastric cancer. Methods: We analysed original data from six cohort studies that measured green tea consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model. Results: During 2 285 968 person-years of follow-up for a total of 219 080 subjects, 3577 cases of gastric cancer were identified. Compared with those drinking <1 cup/day, no significant risk reduction for gastric cancer was observed with increased green tea consumption in men, even in stratified analyses by smoking status and subsite. In women, however, a significantly decreased risk was observed for those with consumption of ≥5 cups/day (multivariate-adjusted pooled HR = 0.79, 95% confidence interval (CI) = 0.65 to 0.96). This decrease was also significant for the distal subsite (HR = 0.70, 95% CI = 0.50 to 0.96). In contrast, a lack of association for proximal gastric cancer was consistently seen in both men and women. Conclusions: Green tea may decrease the risk of distal gastric cancer in women.
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U2 - 10.1136/gut.2008.166710
DO - 10.1136/gut.2008.166710
M3 - Article
C2 - 19505880
AN - SCOPUS:70349315073
VL - 58
SP - 1323
EP - 1332
JO - Gut
JF - Gut
SN - 0017-5749
IS - 10
ER -