Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting

Hua Jie Wang, Ying Cao, Cai Feng Wang, Shi Zhong Cui, Li Wei Mi, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into " nanomedicine" based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that the nanocomposites exhibited high-efficiency killing ability to tumor cells through lipid peroxidation mediated-membrane disintegration route. The safety studies in BALB/c mice didn't detect injection anaphylaxis, hemolysis and cytotoxicity. More interestingly, the nano-composites could specially accumulate in liver and kidney, which will be helpful for targeting cure to these regional cancers.

Original languageEnglish
Article number24387
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Apr 14

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting'. Together they form a unique fingerprint.

Cite this