Grazing-exit and micro X-ray fluorescence analyses for chemical microchips

Kouichi Tsuji, Tetsuya Emoto, Yosuke Nishida, Eiichiro Tamaki, Yoshikuni Kikutani, Akihide Hibara, Takehiko Kitamori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Grazing-exit x-ray fluorescence (GE-XRF) and micro x-ray fluorescence (μ-XRF) methods were applied to chemical microchips as a detection method. Since an energy-dispersive x-ray detector was used, the simultaneous detection of multiple elements was possible. An analyzing region was especially designed on the microchip so that a sample solution could be dried and concentrated in a suitable area corresponding to the size of the primary x-ray beam. Finally, it was confirmed that both analytical methods could be combined well for use with a microchip. In GE-XRF, the background intensity in the XRF spectrum was reduced at grazing-exit angles. In addition, a good relationship between the x-ray fluorescence intensities and the concentrations of standard solutions that were introduced into the microchip was obtained. This indicates that the GE-XRF method is feasible for trace elemental analysis in chemical microchip systems. In μ-XRF, an attempt was made to concentrate and dry the analyte within a small analyzing region. The preliminary results indicated that the μ-XRF method could be applied for the analysis of microchips. 2005

Original languageEnglish
Pages (from-to)799-803
Number of pages5
Journalanalytical sciences
Issue number7
Publication statusPublished - 2005 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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