Graphene oxide amplified electrogenerated chemiluminescence of quantum dots and its selective sensing for glutathione from thiol-containing compounds

Ying Wang, Jin Lu, Longhua Tang, Haixin Chang, Jinghong Li

    Research output: Contribution to journalArticlepeer-review

    375 Citations (Scopus)

    Abstract

    Here we report a graphene oxide amplified electrogenerated chemiluminescence (ECL) of quantum dots (QDs) platform and its efficient selective sensing for antioxidants. Graphene oxide facilitated the CdTe QDs ·+ production and triggered O2·- generation. Then, a high yield of CdTe QDs* was formed due to the combination of CdTeQDs·+ and O2 ·-, leading to an ∼5-fold ECL amplification. Glutathione is the most abundant cellular thiolcontaining peptide, but its selective sensing is an intractable issue in analytical and biochemical communities because its detection is interfered with by some thiol-containing compounds. This platform showed a detection limit of 8.3 μM (S/N ) 3) for glutathione and a selective detection linear dependence from 24 to 214 μM in the presence of 120 μM cysteine and glutathione disulfide. This platform was also successfully used for real sample (eye drug containing glutathione) detection without any pretreatment with a wide linear range from 0.04 to 0.29 μg mL-1.

    Original languageEnglish
    Pages (from-to)9710-9715
    Number of pages6
    JournalAnalytical Chemistry
    Volume81
    Issue number23
    DOIs
    Publication statusPublished - 2009 Dec 1

    ASJC Scopus subject areas

    • Analytical Chemistry

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