Granulocyte-colony stimulating factor-producing esophageal carcinoma: Serum level as a marker for monitoring the effects of treatment

G. Matsumoto, H. Ise, Y. Kimura, H. Inoue, N. Suzuki, H. Ohtani, Hitoshi Ogawa, K. Fukushima, S. Matsuno

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We report here a case of granulocyte-colony stimulating factor (G-CSF)-producing esophageal carcinoma in a 66-year-old man. The International Union Against Cancer (UICC) staging was IV A, and a diagnosis of moderately differentiated squamous cell carcinoma was made, based on histopathology. The diagnosis was based on marked leukocytosis (41500 leukocytes/mm3) and an elevated serum level of G-CSF (154pg/ml). Immunofluorescent histochemistry and northern blot analysis confirmed the expression of G-CSF protein in cancer cells and its mRNA in cancer tissue. We paid special attention to any change in serum G-CSF levels during aggressive cancer treatment. Subtotal esophagectomy induced a significant decrease in G-CSF level. Adjuvant chemo-radiotherapy, targeting celiac lymph node metastasis, and radiotherapy, targeting solitary lung metastasis, together effectively maintained a low serum G-CSF level, despite a recurrence of the tumor in the lungs, in the form of multiple metastases, with an increase in serum G-CSF levels. The patient's clinical course suggested that serum G-CSF would be a useful marker for monitoring the effects of treatment on G-CSF-producing carcinoma.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume5
Issue number5
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Adjuvant chemo-radiotherapy
  • G-CSF-producing esophageal carcinoma
  • Granulocyte colony stimulating factor
  • Serum G-CSF level

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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