Granulocyte activation in restenosis after percutaneous transluminal coronary angioplasty

Masato Tsutsui, Hiroaki Shimokawa, Seiya Tanaka, Shingo Yoshihara, Seiji Higuchi, Takeyuki Matsuguchi, Shuichi Okamatsu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


To examine whether or not granulocyte activation is involved in restenosis after percutaneous transluminal coronary angioplasty (PTCA), we prospectively followed the time course of the plasma level of granulocyte elastase, which is an index of granulocyte activation, before and after successful angioplasty in 43 consecutive patients. Restenosis was defined as a more than 50% loss of the initial gain in the coronary diameter achieved by PTCA with more than a 50% resultant stenosis in the follow-up coronary arteriography performed 3 months after PTCA. There was no difference in the level of granulocyte elastase between the 2 groups with (n = 15) and without (n = 28) restenosis before, the day after and 1 month after PTCA. However, 3 months after PTCA, the level of granulocyte elastase was significantly higher in the group with restenosis than in that without restenosis (171±13 vs 147±6 mg/l, P<0.05). The level of granulocyte elastase at 3 months after PTCA also correlated significantly with the percent luminal stenosis at the angioplasty site (P<0.05). These results suggest that granulocyte activation may be involved in restenosis after PTCA.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
Issue number1
Publication statusPublished - 1996


  • Granulocyte elastase
  • Neutrophil
  • Percutaneous transluminal coronary angioplasty (PTCA)
  • Restenosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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