Gram-scale synthesis of (+)-discodermolide

Amos B. Smith; Michael D. Kaufman; Thomas J. Beauchamp; Matthew J. LaMarche; Hirokazu Arimoto

doi:10.1021/ol9910870

Gram-scale synthesis of (+)-discodermolide

Amos B. Smith, Michael D. Kaufman, Thomas J. Beauchamp, Matthew J. LaMarche, Hirokazu Arimoto

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

Abstract

(formula presented) A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.

Original language	English
Pages (from-to)	1823-1826
Number of pages	4
Journal	Organic letters
Volume	1
Issue number	11
DOIs	https://doi.org/10.1021/ol9910870
Publication status	Published - 1999 Dec 2
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9910870

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@article{a58e37f501c44341bf1bc3c302405dc1,

title = "Gram-scale synthesis of (+)-discodermolide",

abstract = "(formula presented) A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.",

author = "Smith, {Amos B.} and Kaufman, {Michael D.} and Beauchamp, {Thomas J.} and LaMarche, {Matthew J.} and Hirokazu Arimoto",

year = "1999",

month = dec,

day = "2",

doi = "10.1021/ol9910870",

language = "English",

volume = "1",

pages = "1823--1826",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Gram-scale synthesis of (+)-discodermolide

AU - Smith, Amos B.

AU - Kaufman, Michael D.

AU - Beauchamp, Thomas J.

AU - LaMarche, Matthew J.

AU - Arimoto, Hirokazu

PY - 1999/12/2

Y1 - 1999/12/2

N2 - (formula presented) A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.

AB - (formula presented) A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.

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UR - http://www.scopus.com/inward/citedby.url?scp=0033518052&partnerID=8YFLogxK

U2 - 10.1021/ol9910870

DO - 10.1021/ol9910870

M3 - Article

C2 - 10836041

AN - SCOPUS:0033518052

SN - 1523-7060

VL - 1

SP - 1823

EP - 1826

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Gram-scale synthesis of (+)-discodermolide

Abstract

ASJC Scopus subject areas

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