Gram-scale synthesis of (+)-discodermolide

Amos B. Smith, Michael D. Kaufman, Thomas J. Beauchamp, Matthew J. LaMarche, Hirokazu Arimoto

Research output: Contribution to journalArticlepeer-review

146 Citations (Scopus)


(formula presented) A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.

Original languageEnglish
Pages (from-to)1823-1826
Number of pages4
JournalOrganic letters
Issue number11
Publication statusPublished - 1999 Dec 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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