TY - JOUR
T1 - Grain consumption before and during pregnancy and birth weight in Japan
T2 - the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
AU - Yonezawa, Yudai
AU - Obara, Taku
AU - Yamashita, Takahiro
AU - Ishikuro, Mami
AU - Murakami, Keiko
AU - Ueno, Fumihiko
AU - Noda, Aoi
AU - Onuma, Tomomi
AU - Sugawara, Junichi
AU - Suzuki, Shigenori
AU - Suganuma, Hiroyuki
AU - Kuriyama, Shinichi
N1 - Funding Information:
We are sincerely grateful to the participants of the TMM BirThree Cohort Study and the staff of the Tohoku Medical Megabank Organization, Tohoku University. The full list of members is available at https://www.megabank.tohoku.ac.jp/english/a200601/. We would also like to thank Editage (www.editage.com ) for English language editing.
Funding Information:
Funding This work was supported by the Japan Agency for Medical Research and Development (AMED), Japan (grant number, JP20km0105001). KAGOME CO., LTD., provided support in the form of salaries for authors YY, TY, SS, and HS.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/2
Y1 - 2022/2
N2 - Background/Objectives: Studies have reported the effects of grain consumption on human health, but the association between maternal grain consumption before and during pregnancy and birth weight remains unclear. We evaluated the association between maternal grain consumption before and during pregnancy and birth weight/low birth weight (LBW). Subjects/Methods: Grain consumption was calculated using two semi-quantitative food frequency questionnaires (FFQs). The two FFQs evaluated consumption from pre- to early pregnancy and then from early to mid-pregnancy, respectively. Information concerning birth weight was obtained from birth records, and multivariable analyses for birth weight and LBW risk were conducted after adjusting for potential confounders. Results: In total, 17,610 pregnant women (age, 31.8 ± 4.9 years; smoked during pregnancy, 16.1%; gestation period, 38.5 ± 2.5 weeks; first childbirth, 45.5%) and their singleton and term new-borns (birth weight, 3061.8 ± 354.1 g; LBW, 5.4%) were included in the analysis. Women in the highest quartile of grain consumption from pre- to early pregnancy had heavier new-borns (β = 22.3; 95% confidence interval (CI): 5.8–38.9) but did not have a significantly lower LBW risk (odds ratio [OR]: 0.87; 95% CI: 0.71–1.07) than women in the lowest quartile. Women in the highest quartile of grain consumption from early to mid-pregnancy also had heavier new-borns (β = 24.1; 95% CI: 7.1–41.1) but did not have a significantly lower LBW risk (OR: 0.85; 95% CI: 0.69–1.05) than women in the lowest quartile. Conclusions: Grain consumption before and during pregnancy was positively associated with birth weight.
AB - Background/Objectives: Studies have reported the effects of grain consumption on human health, but the association between maternal grain consumption before and during pregnancy and birth weight remains unclear. We evaluated the association between maternal grain consumption before and during pregnancy and birth weight/low birth weight (LBW). Subjects/Methods: Grain consumption was calculated using two semi-quantitative food frequency questionnaires (FFQs). The two FFQs evaluated consumption from pre- to early pregnancy and then from early to mid-pregnancy, respectively. Information concerning birth weight was obtained from birth records, and multivariable analyses for birth weight and LBW risk were conducted after adjusting for potential confounders. Results: In total, 17,610 pregnant women (age, 31.8 ± 4.9 years; smoked during pregnancy, 16.1%; gestation period, 38.5 ± 2.5 weeks; first childbirth, 45.5%) and their singleton and term new-borns (birth weight, 3061.8 ± 354.1 g; LBW, 5.4%) were included in the analysis. Women in the highest quartile of grain consumption from pre- to early pregnancy had heavier new-borns (β = 22.3; 95% confidence interval (CI): 5.8–38.9) but did not have a significantly lower LBW risk (odds ratio [OR]: 0.87; 95% CI: 0.71–1.07) than women in the lowest quartile. Women in the highest quartile of grain consumption from early to mid-pregnancy also had heavier new-borns (β = 24.1; 95% CI: 7.1–41.1) but did not have a significantly lower LBW risk (OR: 0.85; 95% CI: 0.69–1.05) than women in the lowest quartile. Conclusions: Grain consumption before and during pregnancy was positively associated with birth weight.
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U2 - 10.1038/s41430-021-00939-w
DO - 10.1038/s41430-021-00939-w
M3 - Article
C2 - 34131299
AN - SCOPUS:85107910497
VL - 76
SP - 261
EP - 269
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 2
ER -