@inproceedings{1fbd4cc5b1ea4aaba4144d55d1a37eff,
title = "Gradient hydrogels for high throughput drug screening",
abstract = "In this study we demonstrate that hydrogels loaded with a concentration gradient of an active molecule can be used as analytical tools for high throughput screening (HTS) and drug discovery applications. We used a microfluidic mixer to fabricate poly(ethylene glycol) (PEG) hydrogels that contained chemical concentration gradients. Each hydrogel was placed in culture medium in the vicinity of preosteoblast MC3T3-E1 cell layers. The controlled release of the toxin from the hydrogel in a gradient manner was used to study the effect of various chemical concentrations on cell viability. Given its simplicity, ease of storage and portability, this platform is a potentially useful approach to screen a range of drug concentrations simultaneously.",
keywords = "Gradient, Hydrogel, Microfluidic, Toxin",
author = "S. Ostrovidov and N. Annabi and F. Dehghani and A. Seidi and M. Ramalingam and H. Kaji and A. Khademhosseini",
year = "2011",
language = "English",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "1463--1465",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}