GPR34 as a lysophosphatidylserine receptor

Kumiko Makide, Junken Aoki

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

GPR34, a P2Y receptor family member, was identified as a candidate lysophosphatidylserine (LysoPS) receptor in 2006. However, it was controversial whether LysoPS is a real ligand for GPR34. Kitamura et al. (GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. J. Biochem. 2012;151:511-518), using several methods for detecting activation of G protein-coupled receptor (GPCR) and chemically synthesized LysoPS analogues, concluded that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position. Furthermore, three additional GPCRs belonging to the P2Y family were recently identified as GPCRs for LysoPS, supporting the idea that GPR34 is a LysoPS receptor.

Original languageEnglish
Pages (from-to)327-329
Number of pages3
JournalJournal of biochemistry
Volume153
Issue number4
DOIs
Publication statusPublished - 2013 Apr

Keywords

  • GPR34
  • lysophosphatidylserine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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