Gold(i)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex

Toshitaka Okamura, Shogo Fujiki, Yoshiharu Iwabuchi, Naoki Kanoh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A benchtop-stable reagent for the catalytic Nicholas reaction was developed. By combining a propargyl dicobalt hexacarbonyl cluster with an ortho-alkynylbenzoate unit and a fluorous tag, introduction of a propargyl hexacarbonyl complex on various aromatic compounds having acid- or base-sensitive functional groups becomes possible by using a gold(i) catalyst. In addition, the presence of a fluorous tag facilitates convenient separation of the target products from byproducts.

Original languageEnglish
Pages (from-to)8522-8526
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number37
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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