Gold nanoparticle-induced formation of artificial protein capsids

Ali D. Malay, Jonathan G. Heddle, Satoshi Tomita, Kenji Iwasaki, Naoyuki Miyazaki, Koji Sumitomo, Hisao Yanagi, Ichiro Yamashita, Yukiharu Uraoka

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.

Original languageEnglish
Pages (from-to)2056-2059
Number of pages4
JournalNano Letters
Volume12
Issue number4
DOIs
Publication statusPublished - 2012 Apr 11
Externally publishedYes

Keywords

  • Gold nanoparticles
  • artificial capsid
  • nanospheres
  • protein remodeling

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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