Gold-catalyzed transesterification of ortho-alkynylbenzoic acid esters: a novel protecting group for alcohols and phenols

Kazuteru Umetsu, Naoki Asao

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Treatment of ortho-alkynylbenzoic acid esters with excess amounts of EtOH in the presence of a gold catalyst results in the liberation of alcohols or phenols in high yields under mild conditions. The protection of alcohols and phenols proceeds smoothly by use of ortho-alkynylbenzoic acid or ortho-iodobenzoyl chloride. Highly chemoselective deprotections are described.

    Original languageEnglish
    Pages (from-to)7046-7049
    Number of pages4
    JournalTetrahedron Letters
    Volume49
    Issue number49
    DOIs
    Publication statusPublished - 2008 Dec 1

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

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