Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

Tienan Jin; Yoshinori Yamamoto

doi:10.1021/ol702455v

Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

Tienan Jin, Yoshinori Yamamoto

SCI - Research and Analytical Center for Giant Molecules

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

(Chemical Equation Presented) The reaction of the internal alkynyl ketones 1 (n = 1) under the combined catalyst, AuCl₃ and AgSbF₆, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n = 0) under the combined catalyst, AuCl₃ and AgOTf, afforded the cyclic enones 3.

Original language	English
Pages (from-to)	5259-5262
Number of pages	4
Journal	Organic letters
Volume	9
Issue number	25
DOIs	https://doi.org/10.1021/ol702455v
Publication status	Published - 2007 Dec 6

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol702455v

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title = "Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones",

abstract = "(Chemical Equation Presented) The reaction of the internal alkynyl ketones 1 (n = 1) under the combined catalyst, AuCl3 and AgSbF6, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n = 0) under the combined catalyst, AuCl3 and AgOTf, afforded the cyclic enones 3.",

author = "Tienan Jin and Yoshinori Yamamoto",

year = "2007",

month = dec,

day = "6",

doi = "10.1021/ol702455v",

language = "English",

volume = "9",

pages = "5259--5262",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "25",

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T1 - Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

AU - Jin, Tienan

AU - Yamamoto, Yoshinori

PY - 2007/12/6

Y1 - 2007/12/6

N2 - (Chemical Equation Presented) The reaction of the internal alkynyl ketones 1 (n = 1) under the combined catalyst, AuCl3 and AgSbF6, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n = 0) under the combined catalyst, AuCl3 and AgOTf, afforded the cyclic enones 3.

AB - (Chemical Equation Presented) The reaction of the internal alkynyl ketones 1 (n = 1) under the combined catalyst, AuCl3 and AgSbF6, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n = 0) under the combined catalyst, AuCl3 and AgOTf, afforded the cyclic enones 3.

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U2 - 10.1021/ol702455v

DO - 10.1021/ol702455v

M3 - Article

C2 - 17988142

AN - SCOPUS:37249012791

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JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 25

ER -

Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

Abstract

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