Gold-catalyzed C-S bond formation from thiols

Mickaël Jean, Jacques Renault, Pierre van de Weghe, Naoki Asao

    Research output: Contribution to journalArticlepeer-review

    61 Citations (Scopus)


    ortho-Alkynylbenzoic acid alkyl esters act as alkylating agents of thiol derivatives with PPh3AuCl in combination with AgOTf in 1,2-dichloroethane at 80 °C. The corresponding sulfide compounds are obtained in good to excellent yields.

    Original languageEnglish
    Pages (from-to)378-381
    Number of pages4
    JournalTetrahedron Letters
    Issue number2
    Publication statusPublished - 2010 Jan 13


    • Gold catalysis
    • Substitution
    • Sulfide

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


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