Abstract
Unprecedented alkylation of silyl enol ethers has been developed by the use of ortho-alkynylbenzoic acid alkyl esters as alkylating agents in the presence of a gold catalyst. The reaction probably proceeds through the gold-induced in situ construction of leaving groups and subsequent nucleophilic attack on the silyl enol ethers. The generated leaving compound abstracts a proton to regenerate the silyl enol ether structure.
Original language | English |
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Article number | 76 |
Pages (from-to) | 648-652 |
Number of pages | 5 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 7 |
DOIs | |
Publication status | Published - 2011 May 20 |
Keywords
- Alkylation
- Gold catalysis
- Leaving group
- Silyl enol ether
- Substitution reaction
ASJC Scopus subject areas
- Organic Chemistry