GMEB1, a novel endogenous caspase inhibitor, prevents hypoxia- and oxidative stress-induced neuronal apoptosis

Tadashi Nakagawa, Kazuhiro Tsuruma, Takashi Uehara, Yasuyuki Nomura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The interaction of glucocorticoid modulatory element-binding protein 1 (GMEB1) with procaspase-2, -8, or -9 prevents caspase oligomerization and maturation. In the present study, we examined the effect of GMEB1 on neuronal apoptosis induced by hypoxia and oxidative stress. GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. We propose that GMEB1 blocks pro-apoptosis signals induced by a variety of stresses.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalNeuroscience Letters
Volume438
Issue number1
DOIs
Publication statusPublished - 2008 Jun 13
Externally publishedYes

Keywords

  • Apoptosis
  • Caspase
  • Hypoxia
  • Inhibitory protein
  • Ischemia
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

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