GM-CSF and G-CSF stimulate the synthesis of histamine and putrescine in the hematopoietic organs in vivo

Yasuo Endo, Takashi Kikuchi, Yoshikazu Takeda, Yasutaka Nitta, Hidemi Rikiishi, Katsuo Kumagai

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Histamine and putrescine (a precursor of polyamines) are formed by histidine decarboxylase (HDC) and ornithine decarboxylase (ODC), respectively. Within a few hours after injection of a lipopolysaccharide (LPS) into mice, HDC is induced in the liver, spleen, lung and bone marrow, and ODC is induced in the liver, spleen and bone marrow. Since LPS is known to stimulate the production of various cytokines, the abilities of various cytokines to induce HDC and ODC in the tissues of mice were examined. IL-2, IL-6, IL-8, IFNγ and M-CSF were ineffective. IL-1α, IL-1β, TNFα and TNFβ induced HDC and ODC, as does LPS. On the other hand, GM-CSF and G-CSF induced HDC and ODC only in the spleen and bone marrow within a few hours after their injection. These results suggest that, in addition to their roles in inflammation or immune responses, HDC and ODC are also involved in an early stage of hematopoiesis.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalImmunology Letters
Volume33
Issue number1
DOIs
Publication statusPublished - 1992 Jun

Keywords

  • G-CSF
  • GM-CSF
  • Hematopoiesis
  • Histamine
  • Histidine decarboxylase
  • Ornithine decarboxylase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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