Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists

Kazunori Motoshima, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Novel glycogen phosphorylase a (GPa) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on α-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Their structure-activity relationships were analyzed. Some of the compounds thus prepared showed potent inhibitory activity against rabbit muscle GPa with more than 10-fold greater efficacy than a typical GPa inhibitor, 1,4-dideoxy-1,4- imino-D-arabinitol.

Original languageEnglish
Pages (from-to)1618-1620
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume32
Issue number9
DOIs
Publication statusPublished - 2009 Sep

Keywords

  • Enzyme inhibitor
  • Glycogen phosphorylase
  • Phthalimide
  • Structure-activity relationship

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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