Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord

Adam T. Guy, Yasuko Nagatsuka, Noriko Ooashi, Mariko Inoue, Asuka Nakata, Peter Greimel, Asuka Inoue, Takuji Nabetani, Akiho Murayama, Kunihiro Ohta, Yukishige Ito, Junken Aoki, Yoshio Hirabayashi, Hiroyuki Kamiguchi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Glycerophospholipids, the structural components of cell membranes, have not been considered to be spatial cues for intercellular signaling because of their ubiquitous distribution. We identified lyso-phosphatidyl-b-D-glucoside (LysoPtdGlc), a hydrophilic glycerophospholipid, and demonstrated its role in modality-specific repulsive guidance of spinal cord sensory axons. LysoPtdGlc is locally synthesized and released by radial glia in a patterned spatial distribution to regulate the targeting of nociceptive but not proprioceptive central axon projections. Library screening identified the G protein-coupled receptor GPR55 as a high-affinity receptor for LysoPtdGlc, and GPR55 deletion or LysoPtdGlc loss of function in vivo caused the misallocation of nociceptive axons into proprioceptive zones. These findings show that LysoPtdGlc/GPR55 is a lipid-based signaling system in glia-neuron communication for neural development.

Original languageEnglish
Pages (from-to)974-977
Number of pages4
JournalScience
Volume349
Issue number6251
DOIs
Publication statusPublished - 2015 Aug 28

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord'. Together they form a unique fingerprint.

  • Cite this

    Guy, A. T., Nagatsuka, Y., Ooashi, N., Inoue, M., Nakata, A., Greimel, P., Inoue, A., Nabetani, T., Murayama, A., Ohta, K., Ito, Y., Aoki, J., Hirabayashi, Y., & Kamiguchi, H. (2015). Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord. Science, 349(6251), 974-977. https://doi.org/10.1126/science.aab3516