TY - JOUR
T1 - Glycated albumin is not significantly correlated with body mass index in patients with acute-onset type 1 diabetes
AU - Hirata, Takumi
AU - Koga, Masafumi
AU - Kasayama, Soji
AU - Morimoto, Jiro
AU - Maruyama, Taro
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: No previous reports have clarified the relationship between glycated albumin (GA) and BMI in patients with acute-onset type 1 diabetes. Methods: We conducted a cross-sectional study evaluating the correlation between GA and BMI in 209 patients with acute-onset type 1 diabetes and in 159 patients with type 2 diabetes who were designated as the control group. The correlation between fasting serum C-peptide immunoreactivity (CPR) and GA or BMI was also evaluated to clarify the impact of insulin secretion capacity on the relationship between GA and BMI. Results: GA was significantly inversely correlated with BMI in patients with type 2 diabetes (r = -. 0.317, p. <. 0.001) but not in patients with type 1 diabetes (r = 0.031, p = NS). In patients with type 2 diabetes, GA was significantly inversely correlated with fasting CPR, and BMI was significantly correlated with fasting CPR. In patients with type 1 diabetes, GA was significantly inversely correlated with fasting CPR (r = -. 0.291, p. <. 0.001), but BMI was not correlated with fasting CPR (r = -. 0.010, p = NS). Conclusions: Unlike in patients with type 2 diabetes, GA was not significantly correlated with BMI in patients with acute-onset type 1 diabetes.
AB - Background: No previous reports have clarified the relationship between glycated albumin (GA) and BMI in patients with acute-onset type 1 diabetes. Methods: We conducted a cross-sectional study evaluating the correlation between GA and BMI in 209 patients with acute-onset type 1 diabetes and in 159 patients with type 2 diabetes who were designated as the control group. The correlation between fasting serum C-peptide immunoreactivity (CPR) and GA or BMI was also evaluated to clarify the impact of insulin secretion capacity on the relationship between GA and BMI. Results: GA was significantly inversely correlated with BMI in patients with type 2 diabetes (r = -. 0.317, p. <. 0.001) but not in patients with type 1 diabetes (r = 0.031, p = NS). In patients with type 2 diabetes, GA was significantly inversely correlated with fasting CPR, and BMI was significantly correlated with fasting CPR. In patients with type 1 diabetes, GA was significantly inversely correlated with fasting CPR (r = -. 0.291, p. <. 0.001), but BMI was not correlated with fasting CPR (r = -. 0.010, p = NS). Conclusions: Unlike in patients with type 2 diabetes, GA was not significantly correlated with BMI in patients with acute-onset type 1 diabetes.
KW - Body mass index
KW - C-peptide immunoreactivity
KW - Glycated albumin
KW - Glycated hemoglobin
KW - Type 1 diabetes
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U2 - 10.1016/j.cca.2014.08.038
DO - 10.1016/j.cca.2014.08.038
M3 - Article
C2 - 25199854
AN - SCOPUS:84907485551
VL - 438
SP - 248
EP - 251
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
ER -
