Glucose uptake is decreased in affected lower leg muscles of hemiparetic persons during level walking

Naoyuki Oi, Masatoshi Itoh, Yoshiko Tobimatsu, Shinichi Konno, Shinichi Kikuchi, Tsutomu Iwaya

Research output: Contribution to journalArticlepeer-review

Abstract

Stroke patients suffer from gait disturbance due to altered leg muscle actions. Many kinesiological studies have investigated muscle actions, but the metabolic activity of muscles in stroke patients remains to be investigated. We therefore evaluated energy consumption in lower extremity muscles during level walking in hemiparetic individuals. Glucose uptake was measured by positron emission tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) in eight hemiparetic (mean age: 56 years) and 11 healthy (mean age: 26 years) participants. Standardized uptake ratio (SUR) was computed in each muscle to express the 18F-FDG-uptake level. SUR was compared across gluteal, thigh, and lower leg muscles and across individual muscles within each muscle group. For each muscle, SUR was compared among the paretic limb of hemiparetic participants, the non-paretic limb of hemiparetic participants, and the right limb of healthy participants. In paretic limbs, mean SUR did not differ between the three muscle groups, or between individual muscles within each muscle group. SURs of paretic lower leg muscles and gluteus minimus muscle were significantly smaller than those of non-paretic limb and healthy participants (p < 0.05). In the non-paretic limb of hemiparetic participants, SUR of the lower leg muscles was larger than that of the thigh muscles (p < 0.05). Unexpectedly, SURs of medial hamstring and posterior tibial muscles were larger in the non-paretic limb of hemiparetic participants, compared to the right limb of healthy participants (p < 0.05). 18F-FDG PET is useful to evaluate energy consumption levels of lower extremity muscles during level walking in hemiparetic individuals.

Original languageEnglish
Pages (from-to)307-315
Number of pages9
JournalTohoku Journal of Experimental Medicine
Volume237
Issue number4
DOIs
Publication statusPublished - 2015 Nov 28

Keywords

  • F-fluorodeoxyglucose
  • Hemiparesis
  • Positron emission tomography
  • Standardized uptake ratio
  • Walking

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Glucose uptake is decreased in affected lower leg muscles of hemiparetic persons during level walking'. Together they form a unique fingerprint.

Cite this