Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca2+ influx and subsequent Ca2+ oscillations

Takashi Tanaka; Kazuaki Nagashima; Nobuya Inagaki; Hidetaka Kioka; Seiji Takashima; Hajime Fukuoka; Hiroyuki Noji; Akira Kakizuka; Hiromi Imamura

doi:10.1074/jbc.M113.499111

Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca²⁺ influx and subsequent Ca²⁺ oscillations

Takashi Tanaka, Kazuaki Nagashima, Nobuya Inagaki, Hidetaka Kioka, Seiji Takashima, Hajime Fukuoka, Hiroyuki Noji, Akira Kakizuka, Hiromi Imamura

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca²⁺ levels. High nonoscillatory ATP levels were sustained during Ca²⁺ oscillations. Conclusion: High ATP levels may be necessary for initial Ca²⁺ influx and subsequent Ca²⁺ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.

Original language	English
Pages (from-to)	2205-2216
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	4
DOIs	https://doi.org/10.1074/jbc.M113.499111
Publication status	Published - 2014 Jan 24
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca2+ levels. High nonoscillatory ATP levels were sustained during Ca2+ oscillations. Conclusion: High ATP levels may be necessary for initial Ca2+ influx and subsequent Ca2+ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.",

author = "Takashi Tanaka and Kazuaki Nagashima and Nobuya Inagaki and Hidetaka Kioka and Seiji Takashima and Hajime Fukuoka and Hiroyuki Noji and Akira Kakizuka and Hiromi Imamura",

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AU - Tanaka, Takashi

AU - Nagashima, Kazuaki

AU - Inagaki, Nobuya

AU - Kioka, Hidetaka

AU - Takashima, Seiji

AU - Fukuoka, Hajime

AU - Noji, Hiroyuki

AU - Kakizuka, Akira

AU - Imamura, Hiromi

PY - 2014/1/24

Y1 - 2014/1/24

N2 - Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca2+ levels. High nonoscillatory ATP levels were sustained during Ca2+ oscillations. Conclusion: High ATP levels may be necessary for initial Ca2+ influx and subsequent Ca2+ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.

AB - Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca2+ levels. High nonoscillatory ATP levels were sustained during Ca2+ oscillations. Conclusion: High ATP levels may be necessary for initial Ca2+ influx and subsequent Ca2+ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.

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Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca²⁺ influx and subsequent Ca²⁺ oscillations

Abstract

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