Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca2+ influx and subsequent Ca2+ oscillations

Takashi Tanaka, Kazuaki Nagashima, Nobuya Inagaki, Hidetaka Kioka, Seiji Takashima, Hajime Fukuoka, Hiroyuki Noji, Akira Kakizuka, Hiromi Imamura

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca2+ levels. High nonoscillatory ATP levels were sustained during Ca2+ oscillations. Conclusion: High ATP levels may be necessary for initial Ca2+ influx and subsequent Ca2+ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.

Original languageEnglish
Pages (from-to)2205-2216
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
Publication statusPublished - 2014 Jan 24

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca<sup>2+</sup> influx and subsequent Ca<sup>2+</sup> oscillations'. Together they form a unique fingerprint.

Cite this