Abstract
Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca2+ levels. High nonoscillatory ATP levels were sustained during Ca2+ oscillations. Conclusion: High ATP levels may be necessary for initial Ca2+ influx and subsequent Ca2+ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.
Original language | English |
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Pages (from-to) | 2205-2216 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2014 Jan 24 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology