Glucose responsive two-step release of hydrogel-immobilized protein

Kazutoshi Murota, Seiji Sakamoto, Kazuaki Kudo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We designed a two-step-release system that enables protein release from hydrogel in response to glucose. In the system, one of the heterodimeric coiled-coil forming peptides was initially fixed to a hydrogel via a boronate-diol interaction. The peptide was specifically released from the hydrogel by externally incoming glucose. As a result, a protein immobilized in another hydrogel was librated owing to the displacement by the peptide at its hydrogel-bound coiled-coil moiety.

Original languageEnglish
Pages (from-to)582-583
Number of pages2
JournalChemistry Letters
Volume37
Issue number6
DOIs
Publication statusPublished - 2008 Jun 5

ASJC Scopus subject areas

  • Chemistry(all)

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