Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers

Masato Noguchi, Atsushi Kobayashi, Shinichiro Shoda, Toru Nakayama

Research output: Contribution to conferencePaper

Abstract

It is well known that protected acyclic sugar carbonates are useful glycosyl donors for chemical glycosylation reaction. Cyclic sugar derivatives, 1,2-(9-carbonylglycopyranoses(glucose carbonate 1), are potential glycosyl donors for glycosidase-catalyzed glycosylation reaction. Here we report the synthesis of glucose carbonate and the screening of hydrolases that recognize this compound. We synthesized the glucose carbonate from D-glucose via three steps. The enzymatic activity was found in some enzyme preparations, such as Sumizyme MC, from Rhizopus sp. in basic media, and in some α-glucosidase preparations from Rhizopus sp. and Bacillus sp. in acidic media.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Glycosyl donor substrate
  • Glycosyl hydrolase
  • Glycosylation reaction

ASJC Scopus subject areas

  • Engineering(all)

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    Noguchi, M., Kobayashi, A., Shoda, S., & Nakayama, T. (2005). Glucose cyclic carbonate as glycosyl donor substrate for derivatization of polymers. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.