Glucose and glutamine metabolism in oral squamous cell carcinoma: Insight from a quantitative metabolomic approach

Tamaki Ogawa, Jumpei Washio, Tetsu Takahashi, Seishi Echigo, Nobuhiro Takahashi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective To characterize the metabolic system of oral squamous cell carcinoma (OSCC) by metabolome analysis. Study Design The metabolome profiles, including the Embden-Meyerhof-Parnas pathway (EMPP), the pentose phosphate pathway, the tricarboxylic acid cycle (TCAC), and amino acids, were obtained from OSCC and its surrounding normal tissues (32 patients) using capillary electrophoresis and a time-of-flight mass spectrometer. Results Enhancement of glucose consumption and lactate production (Warburg effect) was observed in OSCC tissues. The decrease of glucose along with the decrease of the downstream intermediates in the EMPP suggests that incorporated glucose is mainly consumed for biosynthesis. Glutamine consumption with the increase of the intermediates in the last half of the TCAC suggests the involvement of glutaminolysis, in which glutamine is converted to lactate via the last half of the TCAC. Conclusions It is suggested that OSCC tissues show the Warburg effect, which stems from the combined enhancement of glucose consumption and glutaminolysis.

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume118
Issue number2
DOIs
Publication statusPublished - 2014 Aug

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

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