Glucocorticoidal regulation of pituitary vasopressin content in rats

Masaru Shoji, Tokihisa Kimura, Kozo Ota, Masahiro Ohta, Takefumi Mori, Takayuki Sahata, Minoru Yasujima

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1 Citation (Scopus)

Abstract

Although glucocorticoids are known to attenuate vasopressin (AVP) secretion, it is still controversial whether glucocorticoids act on the hypothalamo-neurohypophysial system. We report here glucocorticoidal regulation of pituitary AVP content, which is a specific indicator for the system. The hypothalamic AVP mRNA content and the pituitary AVP content were measured in rats given dexamethasone (2 mg/kg, 2 times over the course of 5 d) or the glucocorticoid receptor antagonist RU-38486 (20 mg/kg, 3 times over the course of 3 d) during euhydration or dehydration. In dexamethasone-treated rats, both the hypothalamic AVP mRNA content and pituitary AVP content decreased after dehydration. In contrast, in the RU-38486 group the hypothalamic AVP mRNA content and pituitary AVP content increased in both euhydrated and dehydrated rats. These results suggest that glucocorticoids may act on hypothalamo-neurohypophysial vasopressinergic system and attenuate its activity under both basal and dehydrated states.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalHypertension Research - Clinical and Experimental
Volume22
Issue number1
DOIs
Publication statusPublished - 1999 Mar

Keywords

  • Dehydration
  • Dexamethasone
  • RU-38486
  • mRNA

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Shoji, M., Kimura, T., Ota, K., Ohta, M., Mori, T., Sahata, T., & Yasujima, M. (1999). Glucocorticoidal regulation of pituitary vasopressin content in rats. Hypertension Research - Clinical and Experimental, 22(1), 39-42. https://doi.org/10.1291/hypres.22.39