Abstract
We previously reported that methylmercury induces brain-specific upregulation of a chemokine gene, the CCL4 gene. In this study, we investigated the changes in gene expression levels of all chemokines in various tissues (cerebellum, cerebrum, kidney, liver, and spleen) of methylmercury-treated mice. We found that methylmercury induced upregulation of the CCL4 gene and the CCL3 gene, in a brain-specific manner. This finding suggests that upregulation of these two chemokine genes mediates selective damage by methylmercury in the central nervous system.
Original language | English |
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Pages (from-to) | 925-929 |
Number of pages | 5 |
Journal | Journal of Toxicological Sciences |
Volume | 38 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- Brain
- Ccl3
- Ccl4
- Chemokine
- Induction
- Methylmercury
ASJC Scopus subject areas
- Toxicology