Global chemokine expression in methylmercury-treated mice: Methylmercury induces brain-specific expression of CCL3 and CCL4

Min Seok Kim, Tsutomu Takahashi, Jin Yong Lee, Gi Wook Hwang, Akira Naganuma

Research output: Contribution to journalLetterpeer-review

10 Citations (Scopus)

Abstract

We previously reported that methylmercury induces brain-specific upregulation of a chemokine gene, the CCL4 gene. In this study, we investigated the changes in gene expression levels of all chemokines in various tissues (cerebellum, cerebrum, kidney, liver, and spleen) of methylmercury-treated mice. We found that methylmercury induced upregulation of the CCL4 gene and the CCL3 gene, in a brain-specific manner. This finding suggests that upregulation of these two chemokine genes mediates selective damage by methylmercury in the central nervous system.

Original languageEnglish
Pages (from-to)925-929
Number of pages5
JournalJournal of Toxicological Sciences
Volume38
Issue number6
DOIs
Publication statusPublished - 2013

Keywords

  • Brain
  • Ccl3
  • Ccl4
  • Chemokine
  • Induction
  • Methylmercury

ASJC Scopus subject areas

  • Toxicology

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