Ginkgo biloba extract EGb 761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer

Yong Joo Park, Hui Yeon Ahn, Ha Ryong Kim, Kyu Hyuck Chung, Seung Min Oh

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Ginkgo biloba has been used in herbal medicines for thousands of years. Although a standard G. biloba extract, EGb 761 has been used to improve cognition in breast cancer patients, its effects on breast cancer are unknown. Therefore, we investigated the antitumorigenic effects of EGb 761 using an in vitro cell model and an in vivo xenograft model. EGb 761 significantly inhibited aromatase activity in aromatase over-expressing MCF-7 cells (MCF-7 AROM). In addition, EGb 761 exposure reduced cytochrome p450 aromatase (CYP19) mRNA and protein expression; CYP19 promoter I.3 and PII expression particularly decreased. These inhibitory effects on aromatase were accompanied by reduced 17β-estradiol levels in MCF-7 AROM cells. For elucidating antitumorigenic effects, MCF-7 AROM cells were implanted in BALB/c nude mice prior to oral EGb 761 treatment for 3 weeks. EGb 761 reduced the tumor size and significantly reduced tumor CYP19 mRNA expression. Taken together, our results indicated that EGb 761 inhibited aromatase and exerted antitumor effects on breast cancer cells both in vitro and in vivo. These findings suggest that EGb761 may be a useful aromatase inhibitor for the treatment for estrogen-sensitive breast cancer.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalFood and Chemical Toxicology
Volume87
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • 17β-estradiol biosynthesis
  • Aromatase inhibitor
  • Aromatase promoters
  • Breast cancer
  • EGb 761
  • Xenograft

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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