Giant enhancement of fluctuation in small biological systems under external fields

Kumiko Hayashi, Shin Hasegawa, Satoshi P. Tsunoda

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1 Citation (Scopus)

Abstract

The giant enhancement (GE) of fluctuation under an external field is a universal phenomenon predicted by the theoretical analysis given in (Reimann et al 2001 Phys. Rev. Lett.). Here, we propose the application of the theory of the GE of fluctuation to estimate the energy barrier of a biomolecule that exhibits its function subject to thermal noise. The rotary motor protein F1 was used as a model, which is a component of FoF1 adenosine triphosphate (ATP)-synthase. In the single-molecule experiment on F1, the diffusion coeffcients of a rotary probe attached to F1, which characterised the fluctuation of the system, were measured under the influence of an electrorotary field. These diffusion coeffcients were then used to estimate a highenergy barrier of the rotary potential of F1 based on the theory of the GE of fluctuation. Furthermore, the ion channel protein channelrhodopsin (ChR) was used as another research model. The current fluctuations of ions moving through ChR were numerically investigated using a simulation model of the protein in the presence of an external voltage. The energy barrier for ion conduction is discussed based on the current fluctuations.

Original languageEnglish
Article number054028
JournalJournal of Statistical Mechanics: Theory and Experiment
Volume2016
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • Fluctuations (experiments)
  • Fluctuations (theory)
  • Single molecule

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Statistics, Probability and Uncertainty

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