Germicidal activity against carbapenem/colistin-resistant enterobacteriaceae using a quantitative carrier test method

Hajime Kanamori; William A. Rutala; Maria F. Gergen; Emily E. Sickbert-Bennett; David J. Webera

doi:10.1128/AAC00318-18

Germicidal activity against carbapenem/colistin-resistant enterobacteriaceae using a quantitative carrier test method

Hajime Kanamori, William A. Rutala, Maria F. Gergen, Emily E. Sickbert-Bennett, David J. Webera

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Susceptibility to germicides for carbapenem/colistin-resistant Enterobacteriaceae is poorly described. We investigated the efficacy of multiple germicides against these emerging antibiotic-resistant pathogens using the disc-based quantitative carrier test method that can produce results more similar to those encountered in health care settings than a suspension test. Our study results demonstrated that germicides commonly used in health care facilities likely will be effective against carbapenem/colistin-resistant Enterobacteriaceae when used appropriately in health care facilities.

Original language	English
Article number	e00318-18
Journal	Antimicrobial agents and chemotherapy
Volume	62
Issue number	7
DOIs	https://doi.org/10.1128/AAC00318-18
Publication status	Published - 2018 Jul
Externally published	Yes

Keywords

Antiseptics
Carbapenem-resistant enterobacteriaceae
Colistin-resistant enterobacteriaceae
Disinfectants
Efficacy
Germicides
Klebsiella pneumoniae carbapenemase
Mcr-1

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1128/AAC00318-18

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title = "Germicidal activity against carbapenem/colistin-resistant enterobacteriaceae using a quantitative carrier test method",

abstract = "Susceptibility to germicides for carbapenem/colistin-resistant Enterobacteriaceae is poorly described. We investigated the efficacy of multiple germicides against these emerging antibiotic-resistant pathogens using the disc-based quantitative carrier test method that can produce results more similar to those encountered in health care settings than a suspension test. Our study results demonstrated that germicides commonly used in health care facilities likely will be effective against carbapenem/colistin-resistant Enterobacteriaceae when used appropriately in health care facilities.",

keywords = "Antiseptics, Carbapenem-resistant enterobacteriaceae, Colistin-resistant enterobacteriaceae, Disinfectants, Efficacy, Germicides, Klebsiella pneumoniae carbapenemase, Mcr-1",

author = "Hajime Kanamori and Rutala, {William A.} and Gergen, {Maria F.} and Sickbert-Bennett, {Emily E.} and Webera, {David J.}",

note = "Funding Information: We thank Mary Hinkle at Walter Reed Army Institute of Research for providing us with E. coli MRSN 388634. This study was supported by internal funding from UNC Health Care. H.K. received financial support necessary for studying abroad from the Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. Funding Information: We thank Mary Hinkle at Walter Reed Army Institute of Research for providing us with E. coli MRSN 388634. This study was supported by internal funding from UNC Health Care. H.K. received financial support necessary for studying abroad from the Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. W.A.R. and D.J.W. are consultants for PDI.",

year = "2018",

month = jul,

doi = "10.1128/AAC00318-18",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

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T1 - Germicidal activity against carbapenem/colistin-resistant enterobacteriaceae using a quantitative carrier test method

AU - Kanamori, Hajime

AU - Rutala, William A.

AU - Gergen, Maria F.

AU - Sickbert-Bennett, Emily E.

AU - Webera, David J.

N1 - Funding Information: We thank Mary Hinkle at Walter Reed Army Institute of Research for providing us with E. coli MRSN 388634. This study was supported by internal funding from UNC Health Care. H.K. received financial support necessary for studying abroad from the Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. Funding Information: We thank Mary Hinkle at Walter Reed Army Institute of Research for providing us with E. coli MRSN 388634. This study was supported by internal funding from UNC Health Care. H.K. received financial support necessary for studying abroad from the Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. W.A.R. and D.J.W. are consultants for PDI.

PY - 2018/7

Y1 - 2018/7

N2 - Susceptibility to germicides for carbapenem/colistin-resistant Enterobacteriaceae is poorly described. We investigated the efficacy of multiple germicides against these emerging antibiotic-resistant pathogens using the disc-based quantitative carrier test method that can produce results more similar to those encountered in health care settings than a suspension test. Our study results demonstrated that germicides commonly used in health care facilities likely will be effective against carbapenem/colistin-resistant Enterobacteriaceae when used appropriately in health care facilities.

AB - Susceptibility to germicides for carbapenem/colistin-resistant Enterobacteriaceae is poorly described. We investigated the efficacy of multiple germicides against these emerging antibiotic-resistant pathogens using the disc-based quantitative carrier test method that can produce results more similar to those encountered in health care settings than a suspension test. Our study results demonstrated that germicides commonly used in health care facilities likely will be effective against carbapenem/colistin-resistant Enterobacteriaceae when used appropriately in health care facilities.

KW - Antiseptics

KW - Carbapenem-resistant enterobacteriaceae

KW - Colistin-resistant enterobacteriaceae

KW - Disinfectants

KW - Efficacy

KW - Germicides

KW - Klebsiella pneumoniae carbapenemase

KW - Mcr-1

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ER -

Germicidal activity against carbapenem/colistin-resistant enterobacteriaceae using a quantitative carrier test method

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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