Germ line polymorphisms of p53 and cyp1a1 genes involved in human lung cancer

Kaname Kawajiri, Kei Nakachi, Kazue Imai, Junko Watanabe, Shinichi Hayashi

Research output: Contribution to journalArticle

219 Citations (Scopus)

Abstract

The p53 tumor suppressor gene is mutated in diverse types of human cancer, and the normal allele encodes a nuclear protein that regulates expression of cell cycle-related genes as a transcription factor. The wild-type of p53 protein exists as at least two forms of variants among human populations, ascribed to amino acid replacement at codon 72 of Arg by Pro. In this study, we show that this germ line Arg-Pro polymorphism at codon 72 of the p53 gene is associated with genetically determined susceptibility to smoking-induced lung cancer; a susceptible genotype Pro/Pro has a 1.7-fold higher risk of this cancer compared with other genotypes. This p53 polymorphism modulates risk to smoking-induced lung cancer independently of other genetic risk factors such as germ line polymorphism of CYP1A1 or GST1 genes.

Original languageEnglish
Pages (from-to)1085-1089
Number of pages5
JournalCarcinogenesis
Volume14
Issue number6
DOIs
Publication statusPublished - 1993 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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