Geographic tongue treated with topical tacrolimus

Masaya Ishibashi, Genichi Tojo, Masahiko Watanabe, Takahiro Tamabuchi, Takashi Masu, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Background: Geographic tongue, or benign migratory glossitis, is usually an asymptomatic inflammatory disorder of the tongue mucosa of unknown etiology. It is characterized by circinate, erythematous, ulcer-like lesions of the dorsum and lateral border of the tongue due to loss of filiform papillae of the tongue epithelium. Symptomatic treatments have not been evaluated rigorously. Main observation: We describe herein two cases of adult patients with persistent and painful geographic tongue successfully treated with topical application of 0.1% tacrolimus ointment. Conclusion: To our knowledge, this is the first report of successful treatment with topical 0.1% tacrolimus for symptomatic geographic tongue. Clinical trials are needed to confirm the efficacy and the safety of topical tacrolimus in treating geographic tongue.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalJournal of Dermatological Case Reports
Issue number4
Publication statusPublished - 2010


  • Benign migratory glossitis
  • Calcineurin inhibitors
  • Geographic tongue
  • Tacrolimus
  • Treatment

ASJC Scopus subject areas

  • Dermatology


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