Geographic range expansion of tetrodotoxin in amphibians – First record in Atelopus hoogmoedi from the Guiana Shield

Dietrich Mebs, Max Lorentz, Mari Yotsu-Yamashita, Daniela C. Rößler, Raffael Ernst, Stefan Lötters

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

For the first time, alcohol extracts of Atelopus hoogmoedi from the Guiana Shield in Suriname and Guyana were analyzed for the presence of tetrodotoxin (TTX) and of its analogues by high resolution hydrophilic interaction liquid chromatography/mass spectrometry. One specimen from Suriname was found to contain TTX and 4-epiTTX. Using a monoclonal antibody-based immunohistochemical staining technique, TTX was localized mainly in the granular glands and epithelium of the skin, but not in internal organs except liver showing weak TTX-positive reaction. In two specimens collected in Guyana, none of the toxins were detected.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalToxicon
Volume150
DOIs
Publication statusPublished - 2018 Aug

Keywords

  • Atelopus hoogmoedi
  • Guiana Shield
  • Monoclonal antibody
  • Tetrodotoxin
  • Tissue distribution

ASJC Scopus subject areas

  • Toxicology

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