Genotypes at chromosome 22q12-13 are associated with HIV-1-exposed but uninfected status in Italians

Yasuyoshi Kanari, Mario Clerici, Hiroyuki Abe, Hiroyuki Kawabata, Daria Trabattoni, Sergio Lo Caputo, Francesco Mazzotta, Hironori Fujisawa, Atsuko Niwa, Chiaki Ishihara, Yumiko A. Takei, Masaaki Miyazawa

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30 Citations (Scopus)

Abstract

Objective: Despite multiple and repeated exposures to HIV-1, some individuals possess no detectable HIV genome and show T-cell memory responses to the viral antigens. HIV-1-reactive mucosal IgA detected in such uninfected individuals suggests their possible immune resistance against HIV. We tested if the above HIV-1-exposed but uninfected status was associated with genetic markers other than a homozygous deletion of the CCR5 gene. Methods: Based on our mapping in chromosome 15 of a gene controlling the production of neutralizing antibodies in a mouse retrovirus infection, we genotyped 42 HIV-1-exposed but uninfected Italians at polymorphic loci in the syntenic segment of human chromosome 22, and compared them with 49 HIV-1-infected and 47 uninfected healthy control individuals by a closed testing procedure. Results: A significant association was found between chromosome 22q12-13 genotypes and a putative dominant locus conferring anti-HIV-1 immune responses in the exposed but uninfected individuals. Distributions of linkage disequilibrium across chromosome 22 also differed between the exposed but uninfected and two other phenotypic groups. Conclusions: The data indicated the presence of a new genetic factor associated with the HIV-1-exposed but uninfected status.

Original languageEnglish
Pages (from-to)1015-1024
Number of pages10
JournalAIDS
Volume19
Issue number10
DOIs
Publication statusPublished - 2005 Jul 1

Keywords

  • Association study
  • Chromosome 22
  • Exposed seronegatives
  • Genetic background
  • HIV-1
  • Neutralizing antibody
  • Synteny

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Kanari, Y., Clerici, M., Abe, H., Kawabata, H., Trabattoni, D., Lo Caputo, S., Mazzotta, F., Fujisawa, H., Niwa, A., Ishihara, C., Takei, Y. A., & Miyazawa, M. (2005). Genotypes at chromosome 22q12-13 are associated with HIV-1-exposed but uninfected status in Italians. AIDS, 19(10), 1015-1024. https://doi.org/10.1097/01.aids.0000174447.48003.dd