Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human

O. Tanabe, S. Akira, T. Kamiya, G. G. Wong, T. Hirano, T. Kishimoto

Research output: Contribution to journalArticlepeer-review

239 Citations (Scopus)

Abstract

The genomic clone of mouse IL-6 was isolated and compared with the human IL-6 gene. The comparison revealed that the mouse IL-6 consists of five exons and four introns and that the overall organization is similar to that of the human IL-6 gene although the third intron is about 2 kb longer. The sequence similarity in the coding region is about 60%, whereas the 3'-untranslated region and the first 300-bp sequence of the 5'-flanking region are highly conserved (>80%). Several sequence blocks with high homology are also found in the introns. Furthermore, sequences similar to transcriptional enhancer elements such as the c-fos serum responsive element and the consensus sequences for cAMP induction, activator protein 1 binding, and glucocorticoid receptor binding are identified within the highly conserved 5'-flanking regions of the genes from the two species. These sequences may play an important role in transcriptional activation of the IL-6 gene.

Original languageEnglish
Pages (from-to)3875-3881
Number of pages7
JournalJournal of Immunology
Volume141
Issue number11
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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