Genomic Imprinting in Mammals

Hisato Kobayashi, Takahiro Arima

Research output: Contribution to journalArticlepeer-review

Abstract

Genomic imprinting describes the epigenetic phenomenon is that the parent's origin is marked on genome. The phenomenon is unique to placental mammals, and causes parent-of-origin-specific monoallelic expression of most of imprinted genes. The previous studies on mice clarified that these gene expression control required the sex-specific differences of DNA methylation which were established in oogenesis or spermatogenesis. In this paper, we review the relevance of genomic imprinting mechanism and DNA methylation.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalJournal of Mammalian Ova Research
Volume23
Issue number4
DOIs
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • DNA methylation
  • Genomic imprinting
  • Germ cell
  • Imprinted gene

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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