Abstract
Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.
Original language | English |
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Pages (from-to) | 1745-1749 |
Number of pages | 5 |
Journal | Japanese Journal of Cancer and Chemotherapy |
Volume | 38 |
Issue number | 11 |
Publication status | Published - 2011 Nov |
Keywords
- DNA methyltransferase
- Epigenetics
- Genomic imprinting
- Histone modifier
ASJC Scopus subject areas
- Oncology
- Cancer Research