TY - JOUR
T1 - Genomic imprinting and carcinogenesis
AU - Arima, Takahiro
AU - Hiura, Hitoshi
AU - Okae, Hiroaki
AU - Miyauchi, Naoko
AU - Satou, Fumi
N1 - Funding Information:
detail, but it is relevant that at least one gene on chromosome 11, insulin-like-growth-factor II, is transcribed at high levels in all Wilms’ tumours so far tested.27 It is also possible that familial and individual variations in genomic imprinting could explain the anomalies in familial Wilms’ tumour inheritance which are at present put down to delayed mutations and variable "host resistance" .25 It is posible that retinoblastoma and other childhood and adult cancers may also involve genomic imprinting mechanisms. The hypothesis presented here describes genetic events that may be important in carcinogenesis. It might also form the basis of a prognostic indicator for cancer-prone families and should stimulate clinical geneticists to look in a new way at the pedigree data that have been assembled on a variety of human tumours. This research was supported by the Cancer Society of New Zealand.
PY - 2011/11
Y1 - 2011/11
N2 - Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.
AB - Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.
KW - DNA methyltransferase
KW - Epigenetics
KW - Genomic imprinting
KW - Histone modifier
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M3 - Review article
C2 - 22083177
AN - SCOPUS:84856024338
VL - 38
SP - 1745
EP - 1749
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 11
ER -
