Genomic imprinting and carcinogenesis

Takahiro Arima; Hitoshi Hiura; Hiroaki Okae; Naoko Miyauchi; Fumi Satou

Genomic imprinting and carcinogenesis

Takahiro Arima, Hitoshi Hiura, Hiroaki Okae, Naoko Miyauchi, Fumi Satou

Medicine

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.

Original language	English
Pages (from-to)	1745-1749
Number of pages	5
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	38
Issue number	11
Publication status	Published - 2011 Nov

Keywords

DNA methyltransferase
Epigenetics
Genomic imprinting
Histone modifier

ASJC Scopus subject areas

Oncology
Cancer Research

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AU - Arima, Takahiro

AU - Hiura, Hitoshi

AU - Okae, Hiroaki

AU - Miyauchi, Naoko

AU - Satou, Fumi

PY - 2011/11

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N2 - Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.

AB - Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.

KW - DNA methyltransferase

KW - Epigenetics

KW - Genomic imprinting

KW - Histone modifier

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M3 - Review article

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JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

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ER -

Genomic imprinting and carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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