Genomic imprinting and carcinogenesis

Takahiro Arima, Hitoshi Hiura, Hiroaki Okae, Naoko Miyauchi, Fumi Satou

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.

Original languageEnglish
Pages (from-to)1745-1749
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume38
Issue number11
Publication statusPublished - 2011 Nov

Keywords

  • DNA methyltransferase
  • Epigenetics
  • Genomic imprinting
  • Histone modifier

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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