Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

T. Furukawa, T. Yatsuoka, E. M. Youssef, T. Abe, T. Yokoyama, S. Fukushige, E. Soeda, M. Hoshi, Y. Hayashi, M. Sunamura, M. Kobari, A. Horii

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalCytogenetics and Cell Genetics
Volume82
Issue number3-4
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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