Genome-wide linkage analysis of mandibular prognathism in Korean and Japanese patients

T. Yamaguchi, S. B. Park, A. Narita, K. Maki, I. Inoue

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

The existence of familial aggregation of mandibular prognathism (MP) suggests that genetic components play an important role in its etiology. In this study, a genome-wide linkage analysis to identify loci susceptible to MP was conducted with 90 affected sibling-pairs in 42 families, comprised of 40 Korean sibling-pairs and 50 Japanese sibling-pairs. Two non-parametric linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to MP at chromosomes 1p36, 6q25, and 19p13.2. The best evidence of linkage was detected near D1S234 (maximum Z lr = 2.51, P = 0.0012). In addition, evidence of linkage was observed near D6S305 (maximum Zlr = 2.23, P = 0.025) and D19S884 (maximum Zlr = 1.93, P = 0.0089). Identification of the susceptible genes in the linkage regions will pave the way for insights into the molecular pathways that cause MP, especially overgrowth of the mandible, and may lead to the development of novel therapeutic tools.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of dental research
Volume84
Issue number3
DOIs
Publication statusPublished - 2005 Mar
Externally publishedYes

Keywords

  • Japanese
  • Korean
  • Linkage analysis
  • Mandibular prognathism

ASJC Scopus subject areas

  • Dentistry(all)

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