Genome-wide integrative analysis of copy number segments and corresponding gene expression profile

Yutaka Fukuoka, Ken Miyaguchi, Hiroshi Mizushima, Hiroshi Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We performed trend analyses between the lengths of DNA copy number (CN) segments and corresponding gene expression profiles from microarray data in hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC). Significant correlations were observed in CN gain of HCC and CRC (p>0.05). The trend of the CN loss showed a significant correlation in HCC whereas there was no correlation between the length of CN loss segments and gene expression in CRC. Our findings suggest that the influence of CN on gene expression highly depends on the length of CN region, especially in the case of CN gain. To the best of our knowledge, this is the first study describing the correlation between lengths of CN alteration segments and expression profiles of corresponding genes.

Original languageEnglish
Title of host publication2012 Proceedings of SICE Annual Conference, SICE 2012
PublisherSociety of Instrument and Control Engineers (SICE)
Pages783-786
Number of pages4
ISBN (Print)9781467322591
Publication statusPublished - 2012 Jan 1
Event2012 51st Annual Conference on of the Society of Instrument and Control Engineers of Japan, SICE 2012 - Akita, Japan
Duration: 2012 Aug 202012 Aug 23

Publication series

NameProceedings of the SICE Annual Conference

Other

Other2012 51st Annual Conference on of the Society of Instrument and Control Engineers of Japan, SICE 2012
CountryJapan
CityAkita
Period12/8/2012/8/23

Keywords

  • DNA copy number alteration
  • bioinformatics
  • cancer
  • gene expression
  • life engineering

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Electrical and Electronic Engineering

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