Abstract
We performed trend analyses between the lengths of DNA copy number (CN) segments and corresponding gene expression profiles from microarray data in hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC). Significant correlations were observed in CN gain of HCC and CRC (p>0.05). The trend of the CN loss showed a significant correlation in HCC whereas there was no correlation between the length of CN loss segments and gene expression in CRC. Our findings suggest that the influence of CN on gene expression highly depends on the length of CN region, especially in the case of CN gain. To the best of our knowledge, this is the first study describing the correlation between lengths of CN alteration segments and expression profiles of corresponding genes.
| Original language | English |
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| Title of host publication | 2012 Proceedings of SICE Annual Conference, SICE 2012 |
| Publisher | Society of Instrument and Control Engineers (SICE) |
| Pages | 783-786 |
| Number of pages | 4 |
| ISBN (Print) | 9781467322591 |
| Publication status | Published - 2012 Jan 1 |
| Event | 2012 51st Annual Conference on of the Society of Instrument and Control Engineers of Japan, SICE 2012 - Akita, Japan Duration: 2012 Aug 20 → 2012 Aug 23 |
Publication series
| Name | Proceedings of the SICE Annual Conference |
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Other
| Other | 2012 51st Annual Conference on of the Society of Instrument and Control Engineers of Japan, SICE 2012 |
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| Country | Japan |
| City | Akita |
| Period | 12/8/20 → 12/8/23 |
Keywords
- DNA copy number alteration
- bioinformatics
- cancer
- gene expression
- life engineering
ASJC Scopus subject areas
- Control and Systems Engineering
- Computer Science Applications
- Electrical and Electronic Engineering
UN SDGs
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