@inproceedings{4996ece31df9461c9b42a9533d3d3445,
title = "Genome-wide integrative analysis of copy number segments and corresponding gene expression profile",
abstract = "We performed trend analyses between the lengths of DNA copy number (CN) segments and corresponding gene expression profiles from microarray data in hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC). Significant correlations were observed in CN gain of HCC and CRC (p>0.05). The trend of the CN loss showed a significant correlation in HCC whereas there was no correlation between the length of CN loss segments and gene expression in CRC. Our findings suggest that the influence of CN on gene expression highly depends on the length of CN region, especially in the case of CN gain. To the best of our knowledge, this is the first study describing the correlation between lengths of CN alteration segments and expression profiles of corresponding genes.",
keywords = "DNA copy number alteration, bioinformatics, cancer, gene expression, life engineering",
author = "Yutaka Fukuoka and Ken Miyaguchi and Hiroshi Mizushima and Hiroshi Tanaka",
year = "2012",
month = jan,
day = "1",
language = "English",
isbn = "9781467322591",
series = "Proceedings of the SICE Annual Conference",
publisher = "Society of Instrument and Control Engineers (SICE)",
pages = "783--786",
booktitle = "2012 Proceedings of SICE Annual Conference, SICE 2012",
note = "2012 51st Annual Conference on of the Society of Instrument and Control Engineers of Japan, SICE 2012 ; Conference date: 20-08-2012 Through 23-08-2012",
}
