Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Izuho Hatada; Sumiyo Morita; Mika Kimura; Takuro Horii; Riu Yamashita; Kenta Nakai

doi:10.1007/s10038-007-0228-0

Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Izuho Hatada, Sumiyo Morita, Mika Kimura, Takuro Horii, Riu Yamashita, Kenta Nakai

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Journal of Human Genetics
Volume	53
Issue number	2
DOIs	https://doi.org/10.1007/s10038-007-0228-0
Publication status	Published - 2008 Feb

Keywords

Demethylation
Epigenetics
Genome-wide
Methylation
Profiling

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1007/s10038-007-0228-0

Cite this

@article{1cb6afca1895429e9afb5ee85e79aa06,

title = "Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells",

abstract = "Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.",

keywords = "Demethylation, Epigenetics, Genome-wide, Methylation, Profiling",

author = "Izuho Hatada and Sumiyo Morita and Mika Kimura and Takuro Horii and Riu Yamashita and Kenta Nakai",

year = "2008",

month = feb,

doi = "10.1007/s10038-007-0228-0",

language = "English",

volume = "53",

pages = "185--191",

journal = "Jinrui idengaku zasshi. The Japanese journal of human genetics",

issn = "1434-5161",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

AU - Hatada, Izuho

AU - Morita, Sumiyo

AU - Kimura, Mika

AU - Horii, Takuro

AU - Yamashita, Riu

AU - Nakai, Kenta

PY - 2008/2

Y1 - 2008/2

N2 - Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.

AB - Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.

KW - Demethylation

KW - Epigenetics

KW - Genome-wide

KW - Methylation

KW - Profiling

UR - http://www.scopus.com/inward/record.url?scp=38949162923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38949162923&partnerID=8YFLogxK

U2 - 10.1007/s10038-007-0228-0

DO - 10.1007/s10038-007-0228-0

M3 - Article

C2 - 18200438

AN - SCOPUS:38949162923

VL - 53

SP - 185

EP - 191

JO - Jinrui idengaku zasshi. The Japanese journal of human genetics

JF - Jinrui idengaku zasshi. The Japanese journal of human genetics

SN - 1434-5161

IS - 2

ER -

Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this