Abstract
Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.
Original language | English |
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Pages (from-to) | 185-191 |
Number of pages | 7 |
Journal | Journal of Human Genetics |
Volume | 53 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2008 Feb |
Keywords
- Demethylation
- Epigenetics
- Genome-wide
- Methylation
- Profiling
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)