Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Izuho Hatada, Sumiyo Morita, Mika Kimura, Takuro Horii, Riu Yamashita, Kenta Nakai

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalJournal of Human Genetics
Volume53
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

Keywords

  • Demethylation
  • Epigenetics
  • Genome-wide
  • Methylation
  • Profiling

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Hatada, I., Morita, S., Kimura, M., Horii, T., Yamashita, R., & Nakai, K. (2008). Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells. Journal of Human Genetics, 53(2), 185-191. https://doi.org/10.1007/s10038-007-0228-0