Genome-wide association studies reveal additional related loci for fatty acid composition in a Duroc pig multigenerational population

Shuji Sato, Yoshinobu Uemoto, Takashi Kikuchi, Sachiko Egawa, Kimiko Kohira, Tomomi Saito, Hironori Sakuma, Satoshi Miyashita, Shinji Arata, Keiichi Suzuki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The aim of the present study was to detect quantitative trait loci affecting fatty acid composition in back fat and intramuscular fat in a Duroc pig population comprising seventh-generation pedigrees using genome-wide association studies (GWAS). In total, 305 animals were genotyped using single nucleotide polymorphisms (SNPs) array and five selected SNPs from regions containing known candidate genes related to fatty acid synthesis or metabolism. In total, 24 genome-wide significant SNP regions were detected in 12 traits, and 76 genome-wide suggestive SNP regions were detected in 33 traits. The Sus scrofa chromosome (SSC) 7 at 10.3 Mb was significantly associated with C17:0 in intramuscular fat, while the SSC9 at 13.6 Mb was significantly associated with C14:0 in intramuscular fat. The SSC12 at 1.0 Mb was significantly associated with C14:0 in back fat and the SSC14 at 121.0 Mb was significantly associated with C18:0 in intramuscular fat. These regions not only replicated previously reported loci containing some candidate genes involved in fatty acid composition (fatty acid synthase and stearoyl-CoA desaturase) but also included several additional related loci.

Original languageEnglish
Pages (from-to)1482-1490
Number of pages9
JournalAnimal Science Journal
Volume88
Issue number10
DOIs
Publication statusPublished - 2017 Oct
Externally publishedYes

Keywords

  • Duroc pigs
  • GWAS
  • fatty acid composition
  • known candidate genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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