Genetics of supernumerary tooth formation

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Tooth development is initiated with placode formation followed by thickening of the oral ectoderm-derived dental epithelium. The dental epithelium then undergoes invagination into the dental mesench-yme, which is derived from the cranial neural crest. The subsequent reciprocal interactions between the dental epithelium and mesenchyme, involving a variety of molecules, are important for tooth morphogenesis, as well as for regulation of tooth number. Recent analyses of mouse mutants have provided important insights into the mechanisms underlying tooth development, including supernumerary tooth formation. In this review, we have discussed the molecular basis for the regulation of tooth number and supernumerary tooth formation.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
Journaljournal of oral biosciences
Volume55
Issue number4
DOIs
Publication statusPublished - 2013 Nov

Keywords

  • Mutant mouse
  • Supernumerary tooth
  • Tooth development

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dentistry(all)

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