TY - JOUR
T1 - Genetic origin of malignant trophoblastic neoplasms
AU - Arima, Takahiro
AU - Imamura, Toshiro
AU - Amada, Satoshi
AU - Tsuneyoshi, Masazumi
AU - Wake, Norio
N1 - Funding Information:
The authors thank Dr. A. A. Sandberg for critical comments and advice and Drs. H. Fujita, T. Matsuda, and I. Nishiya for providing surgical specimens. This work was supported in part by Grants-in-Aid for Cancer Research (04152087) and for Scientific Research (02670747) from the Ministry of Education, Science and Culture, Japan, a grant from the Naito Foundation, and a grant from the Sagawa Foundation for Promotion of Cancer Research.
PY - 1994/4
Y1 - 1994/4
N2 - The genetic origin of three trophoblastic neoplasms [two choriocarcinomas and a placental site trophoblast tumor (PSTT)] was determined by analysis of the restriction fragment length polymorphism (RFLP) pattern. One choriocarcinoma, which was believed not illogically to have developed from an antecedent complete mole, contained both paternal and material RFLP alleles and thus was probably the product of a normal fertilization. The other choriocarcinoma was not of gestational origin but had RFLPs homozygous at some loci and heterozygous at others, compatible with the parthenogenic origin of this tumor from a germ cell after meiosis I. The PSTT required amplification of DNA sequences by polymerase chain reaction (PCR) because of the small amount of tumor material available. This tumor contained RFLP alleles from both parents and appeared to have resulted from a previous unrecognized (and abnormal) pregnancy.
AB - The genetic origin of three trophoblastic neoplasms [two choriocarcinomas and a placental site trophoblast tumor (PSTT)] was determined by analysis of the restriction fragment length polymorphism (RFLP) pattern. One choriocarcinoma, which was believed not illogically to have developed from an antecedent complete mole, contained both paternal and material RFLP alleles and thus was probably the product of a normal fertilization. The other choriocarcinoma was not of gestational origin but had RFLPs homozygous at some loci and heterozygous at others, compatible with the parthenogenic origin of this tumor from a germ cell after meiosis I. The PSTT required amplification of DNA sequences by polymerase chain reaction (PCR) because of the small amount of tumor material available. This tumor contained RFLP alleles from both parents and appeared to have resulted from a previous unrecognized (and abnormal) pregnancy.
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U2 - 10.1016/0165-4608(94)90192-9
DO - 10.1016/0165-4608(94)90192-9
M3 - Article
C2 - 8174097
AN - SCOPUS:0028282553
SN - 0165-4608
VL - 73
SP - 95
EP - 102
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
