Genetic origin of malignant trophoblastic neoplasms

Takahiro Arima, Toshiro Imamura, Satoshi Amada, Masazumi Tsuneyoshi, Norio Wake

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


The genetic origin of three trophoblastic neoplasms [two choriocarcinomas and a placental site trophoblast tumor (PSTT)] was determined by analysis of the restriction fragment length polymorphism (RFLP) pattern. One choriocarcinoma, which was believed not illogically to have developed from an antecedent complete mole, contained both paternal and material RFLP alleles and thus was probably the product of a normal fertilization. The other choriocarcinoma was not of gestational origin but had RFLPs homozygous at some loci and heterozygous at others, compatible with the parthenogenic origin of this tumor from a germ cell after meiosis I. The PSTT required amplification of DNA sequences by polymerase chain reaction (PCR) because of the small amount of tumor material available. This tumor contained RFLP alleles from both parents and appeared to have resulted from a previous unrecognized (and abnormal) pregnancy.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - 1994 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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