Genetic linkage analyses of Romano-Ward syndrome (RWS) in 13 Japanese families

Toshihiro Tanaka, Ken ichi Nakahara, Norihiro Kato, Takashi Imai, Tsutomu Yamazaki, Hideshi Tomita, Hiroaki Shimokawa, Hironobu Matsuhashi, Nobuyuki Sato, Motoyuki Matsui, Satoshi Kihira, Akihiko Shimizu, Tetsuya Sano, Noriyuki Haneda, Masaya Kino, Yasushi Miyakita, Rumiko Matsuoka, Ryozo Nagai, Yoshio Yazaki, Yusuke Nakamura

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11 Citations (Scopus)

Abstract

Romano-Ward syndrome (RWS) is an autosomal dominant disorder characterized by prolongation of the electrocardiographic QT interval, with clinical manifestations that include recurrent syncope and sudden death from ventricular arrhythmias. Presymptomatic diagnosis is difficult because of the variability in these signs among carriers, but it is important for clinical management to prevent sudden cardiac death. To find an LQT (long QT) locus in Japanese patients and to identify DNA markers useful for presymptomatic diagnosis, linkage analyses were undertaken in 13 Japanese families with RWS patients by means of two DNA markers located on 11p15.5. One of these marker loci, HRAS, was previously reported to be tightly linked to the LQT locus in another ethnic group. Our analyses of homogeneity suggest evidence for genetic heterogeneity of RWS within the Japanese population.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalHuman Genetics
Volume94
Issue number4
DOIs
Publication statusPublished - 1994 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Tanaka, T., Nakahara, K. I., Kato, N., Imai, T., Yamazaki, T., Tomita, H., Shimokawa, H., Matsuhashi, H., Sato, N., Matsui, M., Kihira, S., Shimizu, A., Sano, T., Haneda, N., Kino, M., Miyakita, Y., Matsuoka, R., Nagai, R., Yazaki, Y., & Nakamura, Y. (1994). Genetic linkage analyses of Romano-Ward syndrome (RWS) in 13 Japanese families. Human Genetics, 94(4), 380-384. https://doi.org/10.1007/BF00201597