Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in saccharomyces cerevisiae

Chihiro Horigome; Ryo Ikeda; Takafumi Okada; Kazuhiko Takenami; Keiko Mizuta

doi:10.1271/bbb.80599

Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in saccharomyces cerevisiae

Chihiro Horigome, Ryo Ikeda, Takafumi Okada, Kazuhiko Takenami, Keiko Mizuta

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.

Original language	English
Pages (from-to)	443-446
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	2
DOIs	https://doi.org/10.1271/bbb.80599
Publication status	Published - 2009
Externally published	Yes

Keywords

Inositol polyphosphate
KCS1
RRS1
Ribosome biogenesis
Saccharomyces cerevisiae

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1271/bbb.80599

Cite this

@article{43f5cc5404384c91ab4801fa5508341e,

title = "Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in saccharomyces cerevisiae",

abstract = "Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.",

keywords = "Inositol polyphosphate, KCS1, RRS1, Ribosome biogenesis, Saccharomyces cerevisiae",

author = "Chihiro Horigome and Ryo Ikeda and Takafumi Okada and Kazuhiko Takenami and Keiko Mizuta",

note = "Funding Information: We thank Dr. Mark D. Rose for yeast genomic DNA library. C.H. was supported by a JSPS Research Fellowship for Young Scientists.",

year = "2009",

doi = "10.1271/bbb.80599",

language = "English",

volume = "73",

pages = "443--446",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "2",

}

TY - JOUR

T1 - Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in saccharomyces cerevisiae

AU - Horigome, Chihiro

AU - Ikeda, Ryo

AU - Okada, Takafumi

AU - Takenami, Kazuhiko

AU - Mizuta, Keiko

N1 - Funding Information: We thank Dr. Mark D. Rose for yeast genomic DNA library. C.H. was supported by a JSPS Research Fellowship for Young Scientists.

PY - 2009

Y1 - 2009

N2 - Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.

AB - Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.

KW - Inositol polyphosphate

KW - KCS1

KW - RRS1

KW - Ribosome biogenesis

KW - Saccharomyces cerevisiae

UR - http://www.scopus.com/inward/record.url?scp=65249123484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249123484&partnerID=8YFLogxK

U2 - 10.1271/bbb.80599

DO - 10.1271/bbb.80599

M3 - Article

C2 - 19202276

AN - SCOPUS:65249123484

SN - 0916-8451

VL - 73

SP - 443

EP - 446

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 2

ER -

Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in saccharomyces cerevisiae

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this