Genetic basis of tissue specificity of vasculitis in MRL/lpr mice

Akihiro Yamada, Tatsuhiko Miyazaki, Ling Min Lu, Masao Ono, Mitsuko R. Ito, Miho Terada, Shiro Mori, Kazuya Hata, Yoshimi Nozaki, Shuichi Nakatsuru, Yusuke Nakamura, Morikazu Onji, Masato Nose

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Objective. To clarify the mode of inheritance of the tissue distribution of vasculitis in MRL/Mp.lpr/lpr (MRL/lpr) lupus-prone mice and to identify the susceptibility loci. Methods. Vasculitis in individual MRL/lpr, C3H/ HeJ-lpr/lpr (C3H/lpr), (MRL/lpr × C3H/lpr)F1, and (MRL/lpr × C3H/lpr)F2 intercross mice was analyzed by histopathologic grading of main branches of the aorta and of medium-sized arteries in the lower limbs. Genomic DNA samples from F2 intercross mice were examined by simple sequence-length polymorphism analysis, and the polymorphic microsatellite markers highly associated with vasculitis in each tissue were determined as vasculitis susceptibility loci. Results. A susceptibility locus with significant linkage to vasculitis of main branches of the aorta was mapped on chromosome 4 at D4Mit213 (map position 13.3cM) selectively in males, while vasculitis of mediumsized arteries in the lower limbs was mapped to different chromosomes: at D8Mit31 on chromosome 8 (map position 33.0) selectively in females and at D5Mit36 on chromosome 5 (map position 65.0). All of these were different from the previously defined loci governing susceptibility to vasculitis involving the kidneys. Conclusion. Systemic vasculitis in MRL/lpr mice is genetically controlled with cumulative effects of multiple gene loci, each of which has tissue specificity.

Original languageEnglish
Pages (from-to)1445-1451
Number of pages7
JournalArthritis and Rheumatism
Issue number5
Publication statusPublished - 2003 May 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


Dive into the research topics of 'Genetic basis of tissue specificity of vasculitis in MRL/lpr mice'. Together they form a unique fingerprint.

Cite this