Genetic association between GHSR1a 5'UTR-microsatellite and n(C>A) loci and growth and carcass traits in Japanese Black cattle

Masanori Komatsu, Tomohito Itoh, Yuki Fujimori, Masahiro Satoh, Yoshiyuki Miyazaki, Hideaki Takahashi, Kazuhiro Shimizu, Aduli E.O. Malau-Aduli, Mitsuo Morita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We carried out a genetic association study between five nucleotide polymorphisms (5'UTR microsatellite ((TG)n), nt-7(C>A), L24V, DelR242 and Intron 1 microsatellite) of the GHSR1a gene and growth and carcass traits in 1285 steers sired by 117 Japanese Black bulls in a progeny testing program. We report herein, a significant association between the 5'UTR microsatellite and nt-7(C>A) loci and growth and carcass traits. We also propose a translational hypothesis that the association is due to differences in the secondary structure of GHSR1b mRNA (the non-spliced type with the 5'UTR microsatellite) among the GHSR1a gene haplotypes. Furthermore, we predicted the potential increase in profitability due to increased carcass weight in cow-calf fattening enterprises through planned matings based on DNA testing of the 5'UTR microsatellite. Statistical analysis revealed that the 5'UTR microsatellite locus had a significant additive effect on carcass weight (CW) and average daily gain (ADG), but not on beef marbling score (BMS). One of the four major microsatellite alleles (19-TG allele) with an allele frequency of 0.145, had a significantly (P<0.0007) desirable effect on CW and ADG. We concluded that the 19-TG allele could potentially be economically useful nucleotide markers for growth and carcass traits in Japanese Black cattle.

Original languageEnglish
Pages (from-to)396-405
Number of pages10
JournalAnimal Science Journal
Volume82
Issue number3
DOIs
Publication statusPublished - 2011 Jun 1
Externally publishedYes

Keywords

  • 5'UTR-microsatellite
  • GHSR
  • Growth and carcass traits
  • Japanese black cattle
  • MRNA secondary structure

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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